Tuesday, December 26, 2023

Keep It Short

OK, I admit it: I’m on Facebook. I still use Twitter – whoops, I mean X. I have an Instagram account but don’t think I’ve ever posted. Although I’ve written about TikTok numerous times, I’ve never actually been on it. And while I am on YouTube, it’s more for clips from movies or TV shows than for videos from creators like MrBeast.  

So forgive me if I’m only belated taking a look at the short form video revolution.

Hint: it's not TV he's watching. Credit: Bing Image Creator

As is often the case, a couple articles related to the topic spurred my attention: Caroline Mimbs Nyce Twitter’s Demise Is About So Much More Than Elon Musk in The Atlantic, and Jessica Toonkel’s Wall Street Journal article Your Kid Prefers YouTube to Netflix. That’s a Problem for Netflix. I urge you to read both.

Ms. Nyce makes that point that, while Elon may be doing a pretty good job damaging Twitter, much of its woes really are due to microblogging falling out of favor. Her take:

In the era of TikTok, the act of posting your two cents in two sentences for strangers to consume is starting to feel more and more unnatural. The lasting social-media imprint of 2023 may not be the self-immolation of Twitter but rather that short-form videos—on TikTok, Instagram, and other platforms—have tightened their choke hold on the internet. Text posts as we’ve always known them just can’t keep up.

She notes that Twitter is still the dominant platform, by far, for microblogging, but quotes a prediction from data.ai: “While platforms like X are likely to maintain a core niche of users, the overall trends show consumers are swapping out text-based social networking apps for photo and video-first platforms.”

“Short-form videos have become an attention vortex,” Ms. Nyce reports, citing figures from Sensor Tower that users spend an average of 91 minutes daily on TikTok and 61 minutes on Instagram.  

Indeed, Insider Intelligence estimates that video’s share of average daily social media went over 50% in 2022, and will reach 60% by 2025. It predicts that the short video “craze” will cool, but admits: “platforms must contend with the reality that consumers still love short videos.”

Meanwhile. Ms. Toonkel quotes a father of a 8 year-old, who has stopped watching shows like “Thomas and Friends”: “Now, all he wants to do is watch gamers and basketball clips and highlights on YouTube.” She adds: “The Levy family learned what has become clear across the media industry: When it comes to children’s entertainment preferences, YouTube trumps all.

She reports: “Netflix’s share of U.S. streaming viewership by 2- to 11-year-olds fell to 21% in September from 25% two years earlier, according to Nielsen. Meanwhile, YouTube’s share jumped to 33% from 29.4% over the same period.” Michael Hirsh, co-founder of WOW Unlimited Media, confirmed: “These viewers are watching on their iPads or on other platforms that have moved to shorter and shorter segments, and it’s a real issue for the streamers.”

Ms. Toonkel cities an animation studio that released one new children’s film on Roblox, and other that premiered on YouTube instead of a streaming service. In both cases, the streaming services were a secondary priority. “It’s really about following the consumer,” the studio’s global chief marketing officer told her.

Two weeks ago Pew Research issued a study directly on point: Teens, Social Media and Technology 2023. YouTube, to no one’s surprise, is the top platform for teens 13 to 17, with 93% using. TikTok (63%), Snapchat (60%), and Instagram (59%) followed. Facebook (33%) and Twitter (20%) are barely an afterthought.

Seventy-one percent of teen YouTube users go on daily, with 16% on “almost constantly.” For TikTok, the corresponding figures were 58% and 17%.

YouTube’s popularity isn’t just among teens, of course. The Social Shepherd compiled some fun YouTube facts, such as: 

  • It has some 2.7 billion monthly users, with 1.5b on YouTube Shorts;
  • There are 122 million daily users;
  • 98% of US internet users are on YouTube monthly, 92% weekly, 62% daily;
  • US children spend 77 minutes daily on YouTube;
  • The aforementioned MrBeast is YouTube’s biggest earner, raking in an estimated $82 million annually;
  • 70% of viewers have made a purchase after seeing the brand on YouTube.

Companies better be paying attention. Ms. Nyce warns: “In a recent survey by Sprout Social, a social-media-analytics tool, 41 percent of consumers said that they want brands to publish more 15- to 30-second videos more than they want any other style of social-media post. Just 10 percent wanted more text-only content.

Digiday’s Krystal Scanlon believes: “The latest pivot toward video is in full swing, and unlike previous occasions, agencies must now master the art of short-form video rather than focusing solely on specific platforms.” She clarifies that not all platforms’ version of short form videos are the same, contrasting TikTok’s “short, engaging, creative videos” with YouTube Short’s “informational or tutorial-style videos.”

Her bottom line: “Simply put, the video content needs to be native to the platform, because consumers are fed up of seeing ads.” As TikTok said when introducing TikTok for Business, “Don’t Make Ads, Make TikToks.”

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Earlier this year Monigle released its Humanizing Brand Experience report. Among other things, it suggested a decline in consumers’ interest in “watching/reading about health and wellness topics,” and an increase in their distrust of healthcare providers.  Neither results are yet dismal, but they underscore that in a short form video world, even healthcare companies need to be rethinking their brand and content strategies.

Detailed web pages of health advice?  Who reads? Catchy TV ads? Who watches? Helpful videos with health information from respected physicians? Too long. Health is complicated, health care is idiosyncratic, so short form anything isn’t natural, but it may now be necessary.  

Those of us of a certain age may not quite understand or appreciate short form videos, but they’re not something we can ignore. Ms. Nyce’s closing thoughts are ominous:

Perhaps the biggest stress test for our short-form-video world has yet to come: the 2024 U.S. presidential election. Elections are where Twitter, and microblogging, have thrived. Meanwhile, in 2020, TikTok was much smaller than what it is now. Starting next year, its true reign might finally begin.
And, I might add, in a time of vaccine skepticism and rampant health misinformation, misleading/simplistic short forms videos pose an existential threat, unless countered by equally effective ones.

Time to up your short form video game, everyone.

Monday, December 18, 2023

A Place to Call Home

Congratulations, America. We have another new record, albeit a dismal one. According to the Department of Housing and Urban Development (HUD), there are now 653,000 homeless people, up 12% from the prior year. As one can imagine, compiling such a number is problematic at best, and no doubt misses a non-trivial number of such unfortunate people.

There but for the grace of God go I.  Credit: Bing Image Creator
“Homelessness is solvable and should not exist in the United States,” said HUD Secretary Marcia L. Fudge. Well, yeah, like kids without enough food, pregnant women without access to adequate prenatal care, or people without health insurance, yet here we are.

HUD says that the increase was driven by people who became for the first time, up some 25%. It attributes this to “a combination of factors, including but not limited to, the recent changes in the rental housing market and the winding down of pandemic protections and programs focused on preventing evictions and housing loss.” As with the recent increase in child poverty, the lessons that we should have learn from our COVID response didn’t survive our willingness to put the pandemic behind us.

Jeff Olivet, executive director of the U.S. Interagency Council on Homelessness, told AP: “The most significant causes are the shortage of affordable homes and the high cost of housing that have left many Americans living paycheck to paycheck and one crisis away from homelessness.” The National Low Income Housing Coalition estimates we’re missing some 7 million affordable housing units, so I suppose we should be relived there are “only” 653,000 homeless people.



“For those on the frontlines of this crisis, it’s not surprising,” Ann Oliva, CEO of the National Alliance to End Homelessness, also told AP. Indeed, we’ve all seen news accounts of homeless encampments spreading seemingly out of control, many of us have spotted homeless people as we go about our daily lives, and yet most of us don’t want either homeless people or low income housing units in our neighborhoods.

We often tell ourselves that homeless people are mentally ill or drug users, but data suggests that most are homeless due to economic reasons.  As many as 60% of them are still working, but just can’t afford housing. Too many of us are one missing paycheck away from being on the street.

They’re more likely to be victims of crimes than criminals; in fact, BBC reports that violence against homeless people – including homicide – seems to be on the rise, although there is no systemic tracking of such violence.

In a searing piece in The Atlantic,  Anne Lowrey blasts our lack of anything resembling a national housing policy. She notes: “…today’s HUD is not much of a housing agency. And it is definitely not much of an urban-development agency.” Secretary Fudge told her: “HUD is doing all in our power to invest in those who have often been left out and left behind.” And that’s a big part of the problem.

As Ms. Lowry laments, despite the obvious housing crisis and record number of homeless,

Yet legislators have not passed a significant bill to get people off the streets and out of shelters. Joe Biden has not signed a law to increase the supply of rental apartments in high-cost regions or to protect families from predatory landlords. Congress has not made more families eligible for housing vouchers, or passed a statute protecting kids from the trauma of eviction, or set a goal for the production of new housing.

“The country’s lack of a national housing policy is part of the reason we are in a housing crisis,” she says, “and Washington needs to take a real role in ending it.

What really got my attention was that a number of states and cities – most of them run by Democrats – want the Supreme court to overturn Martin vs. Boise, which ruled that evicting homeless people who had no choice of indoor housing was “cruel and unusual punishment” and thus unconstitutional. If you want to evict them from their outdoor housing, the court said, you better have places to put them.

Seems reasonable to me. I mean, they’re already homeless; where else do you expect them to go? It doesn’t help that many places are criminalizing homelessness, as though it was a choice those people were making.

I don’t usually look to Texas for solutions to social issues, but when it comes to the homeless, it may be a leader. Over the last decade, Texas has decreased its homeless population by nearly a third, in part because it builds more housing, and less expensive housing.

Cities such as Austin, Houston, and San Antonio have been particular innovators. Houston has cut its homeless population by two-thirds. There was a concerted city-county effort to coordinate the work of public agencies and over 100 non-profits. (Outgoing) Houston Mayor Sylvester Turner brags. “Instead of a hundred NGOs competing with each other, we’ve kind of pulled them all together. They’re now operating under a single umbrella, The Way Home.”

Credit: The Way Home Houston
The focus is to get homeless people into housing first, then address their other issues. As The Way Home says, “first, we give them a key.” Then they work on providing them supportive services to help stabilize their lives. Even law enforcement is on board; Harris County Sheriff Ed Gonzalez says:

…I think it’s important for us to recognize that it really is a public health issue: How can we better develop those systems of care, to better route people where they may need to be, rather than just looking at it through the lens of policing.

That sure beats just breaking up encampments.

Meanwhile, Austin has focused on providing “tiny homes,” while San Antonio has built a huge homeless shelter. It’s important to note that these are local initiatives; Texas itself provides very little state funding for the homeless.  None of these cities has “solved” homelessness, but they’ve shown ways to lessen it.

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Like poverty, homelessness isn’t inevitable; it is a policy choice. Sociologist Matthew Desmond, author of the must-reads Poverty and Evicted, told Ms. Lowrey: “Think of lining up families who qualify for food stamps and only one in four families gets to eat. That’s exactly how we treat housing policy today. It doesn’t make a lot of sense, because, without stable shelter, everything else falls apart.” Accordingly, Ms. Lowrey asserts: “affordable housing for everyone, everywhere, and the end of homelessness should be the policy priority now.

We may not be able to end homelessness, but we can and should stop treating them as undesirables and start treating them as people – people who first and foremost need a place to live. 

Monday, December 11, 2023

From Xenobots to Anthrobots

There were many things I could have written bout this week – e.g., in A.I., in quantum computing, even “transparent wood” -- but when I saw some news about biological robots, I knew I had my topic.

Yep, those are robots -- biological robots. Credit: Gizen Gumuskaya

The news comes from researchers at Tufts University and Harvard’s Wyss Institute. Their paper appeared in Advanced Science, introducing “a spheroid-shaped multicellular biological robot (biobot) platform” that they fondly dubbed “Anthrobots.” Importantly, the Anthrobots are made from human cells.

Let’s back up. In 2020, senior researcher Michael Levin, Ph.D., who holds positions at both Tufts and Harvard, worked with Josh Bongard, Ph.D. of the University of Vermont to create biological robots made from frog embryo cells, which they called Xenobots.  They were pretty impressive, capable of navigating passageways, collecting material, recording information, healing themselves from injury, and even replicating for a few cycles on their own, but the researchers wanted to find out if they could create biological robots from other types of cells – especially human cells.

Well, the new research showed that they could. They started with cells from adult trachea, and without genetic modification were able to demonstrate capabilities beyond those Xenobots had demonstrated. Lead author Gizem Gumuskaya, a PhD. student said: “We wanted to probe what cells can do besides create default features in the body. By reprogramming interactions between cells, new multicellular structures can be created, analogous to the way stone and brick can be arranged into different structural elements like walls, archways or columns.”   

The Anthrobots come in different shapes and sizes, and are capable of different motions. Ms. Gumuskaya is quite excited about their capabilities:

The cells can form layers, fold, make spheres, sort and separate themselves by type, fuse together, or even move. Two important differences from inanimate bricks are that cells can communicate with each other and create these structures dynamically, and each cell is programmed with many functions, like movement, secretion of molecules, detection of signals and more. We are just figuring out how to combine these elements to create new biological body plans and functions—different than those found in nature.



Even better, Ms. Gumuskaya pointed out: “Anthrobots self-assemble in the lab dish. Unlike Xenobots, they don’t require tweezers or scalpels to give them shape, and we can use adult cells – even cells from elderly patients - instead of embryonic cells. It’s fully scalable—we can produce swarms of these bots in parallel, which is a good start for developing a therapeutic tool.”

They tested Anthrobots’ healing capabilities by scratching a layer of neurons, then exposed the gap to a cluster of Anthrobots called a “superbot.”  That triggered neuron growth only in that area. The researchers noted: “Most remarkably, we found that Anthrobots induce efficient healing of defects in live human neural monolayers in vitro, causing neurites to grow into the gap and join the opposite sides of the injury.”

“The cellular assemblies we construct in the lab can have capabilities that go beyond what they do in the body,” said Dr. Levin. “It is fascinating and completely unexpected that normal patient tracheal cells, without modifying their DNA, can move on their own and encourage neuron growth across a region of damage.”

Xi “Charlie” Ren, a tissue engineer at Carnegie Mellon University who was not involved with the research, told Science that the work “is amazing, and groundbreaking,” and “opens the way to personalized medicine.” Ron Weiss, a synthetic biologist at the Massachusetts Institute of Technology who also was not involved with the work added: “Levin demonstrated that cells can be coached to do something they would never have done on their own.”

Some researchers are not yet convinced. Jamie Davies, a developmental biologist at the University of Edinburgh in Scotland, who was not involved in the 2020 study or this recent one, told Scientific American: “I cannot see how these clumps of cells with flailing cilia merit the term ‘bot.” Dr. Levin and his team, of course, don’t believe the movements are random, and that Anthrobots “could be designed to respond to their environment, and travel to and perform functions in the body, or help build engineered tissues in the lab.”

The ultimate hope is that clinicians would be able to use Anthrobots created from a patient’s own cells to perform therapeutic work. Those bots shouldn’t trigger an immune response, would be bioresorbable, and couldn’t survive outside the lab or the body (making risk of any unintended spread minimal).

The researchers see a wide variety of potential uses in health care:

…various applications can be imagined, including but not limited to clearing plaque buildup in the arteries of atherosclerosis patients, bulldozing the excess mucus from the airways of cystic fibrosis patients, and locally delivering drugs of interest in target tissues. The possible applications will represent those arising from exploiting surprising novel behaviors of cells and engineering new ones via future synthetic biology payloads, such as novel enzymes, antibodies, and other ways to manipulate the cells they traverse and interact with. They could also be used as avatars for personalized drug screening[32] having the advantage of behavior over simple organoids, which could be used to screen for a wider range of active, dynamic phenotypes.

That’s 21st century medicine. That’s the kind of health care I want to see.

21st century medicine in action. Credit: Bing Image Creator
The researchers have a number of research areas they want to further explore, including:

  • What other cells can Anthrobots be made of?
  • What other behaviors might they exhibit, and in what environments?
  • What other tissue types can they repair or affect in other ways?
  • Can transcriptional or physiological signatures be read out in living bots, that reflect their past and immediate interactions with surrounding cellular or molecular landscapes?
  • Do they have preferences or primitive learning capacities, with respect to their traversal of richer environments?

As researchers like to say, more research is required – and, from where I’m sitting, eagerly awaited.

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OK, so these aren’t like the cute robots you see doing flips. They’re not the nanobots many of us have been waiting for. We don’t (yet) have to worry about Asimov’s Three Laws of Robotics with them. But, boy, if we’re going to have robots crawling around inside us doing therapeutic things – and we are -- what could be better than a biological robot made from your own cells?

Monday, December 4, 2023

Lead Pipe Cinch

The term “lead pipe cinch” means something that is very easy or certain. Here’s two things that are lead pipe cinches: first, that ingesting lead, such as from the water or the air, is bad for us. It’s especially bad for children, whose cognitive abilities can be impaired. Second, that the Biden Administration’s latest proposal to reduce the lead in our drinking water is not going to accomplish that.

Is it safe? Credit: Bing Image Creator

The new proposed rules would require that lead service lines be replaced within ten years; there are estimated to still be some 9.2 million such lines in the U.S. The trouble is, no one really knows how many there are or where exactly they are, making replacement difficult. So step two of the rules is for an initial inventory by next October. The “acceptable” parts per billion would drop from 15 to 10. Utilities would also have to improve tap sampling and consumer outreach.

“This is the strongest lead rule that the nation has ever seen,” Radhika Fox, the E.P.A.’s assistant administrator for water, told The New York Times. “This is historic progress.”

Erik Olson, an expert with the Natural Resources Defense Council is also hopeful, telling NPR: "We now know that having literally tens of millions of people being exposed to low levels of lead from things like their drinking water has a big impact on the population. We're hoping this new rule will have a big impact."

The EPA estimates the replacement will cost $20b to $30b over the next decade; the 2021 Infrastructure Act allocated $15b, along with 11.7b available from the Drinking Water State Revolving Fund. Of course, the cost will be much higher.

Chicago alone claims it will cost $10b to replace its estimated 400,000 lead pipes. The Wall Street Journal reports: “David LaFrance, CEO of the American Water Works Association, a trade group, said the total cost could “easily exceed” $90 billion. He said the average cost to replace a single lead service line is more than $10,000, nearly double the EPA’s estimate.

Digging up all those lead pipes won't be easy. Or cheap. Credit: Bing Image Creator
If the federal funds aren’t enough, Ms. Fox says: "We strongly, strongly encourage water utilities to pay for it," but you should probably expect customers will end up paying – or that some of those pipes won’t be getting replaced.

It’s not like any of this is catching us by surprise. You probably remember the 2014 scandal with the Flint (MI) water crisis, with all those people lining up for bottled water. You may not remember similar crises in Washington D.C., Newark (NJ), or Benton Harbor (MI). “The Washington, D.C., lead-in-water crisis was far more severe than Flint in every respect,” Yanna Lambrinidou, a medical anthropologist at Virginia Tech and co-founder of the Campaign for Lead Free Water, told AP.

The EPA issued a set of rules around lead pipes in 1991, but those rules were watered down, and little progress has been made since. Ronnie Levin, an EPA researcher at the times, also told AP: “But, you know, we’ve been diddling around for 30 years.”

Because, you know, that’s what we do, especially when fixing a problem costs too much money.

The water companies may replace their water lines but not the ones that go under private property, and the pipes inside homes or offices -- well, you should start thinking about a water filter (ones certified for lead, of course).

You wouldn’t buy a house that you knew had lead paint or had asbestos, but most people don’t know if any part of their water supply comes through lead pipes. Dr. Lambrinidou told Fast Company: “We know that the majority of homes, if not all, have lead-bearing plumbing. And we know from the science that as long as you have lead-bearing plumbing, you are at risk of exposure.”



It shouldn’t be a surprise that the problem is worst in cities and in older housing stock. “This a public health concern that has, unfortunately, spanned generations and an issue that has disproportionately impacted low-income and minority communities,” EPA Administrator Michael Regan said at the EPA briefing. “Everyone in this country should be able to turn on their tap for a glass of water and know that it’s safe to drink.”

"We're trying to right a longstanding wrong here," Radhika Fox, head of the EPA Office of Water, echoed. "We're bending the arc towards equity and justice on this legacy issue."

Experts estimate some 500,000 children have high levels of lead in their blood; that number may be overstated, or wildly low. Adults are at risk as well, especially pregnant women. The EPA believes its rules would generate between $9.8b and 34.8b in economic benefits each year, making it a good return on the replacement investments. But the rub is that those economic benefits are from less cognitive impairments and health disorders, in populations we tend to neglect anyway, and so are much “softer” than the direct budget hits of replacing the pipes.

“We have failed generations of children by not eliminating lead,” Mona Hanna-Attisha, the Michigan pediatrician whose research helped to exposed the 2014 Flint water crisis, told NYT. True, but we’ve been failing generations of kids for generations in many ways, such as child poverty or infant mortality. We have generations of “lost Einsteins," kids who never had a chance to reach their full potential due to their surroundings while growing up, whether from lead in their water, insufficient food, polluted air, or failing public education.

We’re the champs at failing kids. And at addressing structural issues like infrastructure.

The new rules now have a waiting period, and final rules aren’t expected until next fall. Then there will be a waiting period before they go into effect. By the time the lobbyists and the politicians – we can’t afford it! – have their say, I’m not optimistic how much impact the final rules will have.

I’m freaked out that there might be lead in my water lines. I’m saddened that there are perhaps hundreds of thousands, if not millions, of children who will never reach their full potential due to having adsorbed too much lead. And I’m furious that we allow our public goods, like clean water or air, to be compromised by politicians whose only concern is reelection.

We can do better, Sadly, it’s a lead pipe cinch that we probably won’t.